Proteinase 3 promotes formation of multinucleated giant cells and granuloma-like structures in patients with granulomatosis with polyangiitis.

Scott R HendersonHarry HorsleyPaul FrankelMaryam KhosraviTalya GobleStephen CarterMarilina AntonelouRhys D R EvansXiang ZhangTai-Ying ChuHsi-Hsien LinSiamon GordonAlan David Salama

Published in: Annals of the rheumatic diseases (2023)

These data provide a mechanistic basis for granuloma formation in GPA and a rationale for novel therapeutic approaches.

Keyphrases

induced apoptosis
cell cycle arrest
high resolution
clinical trial
big data
endoplasmic reticulum stress
cell death
oxidative stress
cell proliferation
machine learning
artificial intelligence