Preclinical Voxel-Based Dosimetry in Theranostics: a Review.
Arun GuptaMin Sun LeeJoong Hyun KimDong Soo LeeJae Sung LeePublished in: Nuclear medicine and molecular imaging (2020)
Due to the increasing use of preclinical targeted radionuclide therapy (TRT) studies for the development of novel theranostic agents, several studies have been performed to accurately estimate absorbed doses to mice at the voxel level using reference mouse phantoms and Monte Carlo (MC) simulations. Accurate dosimetry is important in preclinical theranostics to interpret radiobiological dose-response relationships and to translate results for clinical use. Direct MC (DMC) simulation is believed to produce more realistic voxel-level dose distribution with high precision because tissue heterogeneities and nonuniform source distributions in patients or animals are considered. Although MC simulation is considered to be an accurate method for voxel-based absorbed dose calculations, it is time-consuming, computationally demanding, and often impractical in daily practice. In this review, we focus on the current status of voxel-based dosimetry methods applied in preclinical theranostics and discuss the need for accurate and fast voxel-based dosimetry methods for pretherapy absorbed dose calculations to optimize the dose computation time in preclinical TRT.
Keyphrases
- monte carlo
- cell therapy
- high resolution
- end stage renal disease
- current status
- ejection fraction
- newly diagnosed
- healthcare
- stem cells
- type diabetes
- photodynamic therapy
- mesenchymal stem cells
- prognostic factors
- molecular dynamics
- case control
- drug delivery
- bone marrow
- molecular dynamics simulations
- mass spectrometry
- quality improvement
- density functional theory
- replacement therapy