Investigation of Clostridium difficile ribotypes in symptomatic patients of a German pediatric oncology center.
Arne SimonMarkus MockNorbert GrafLutz von MüllerPublished in: European journal of pediatrics (2017)
Under strict standard hygiene and contact isolation for symptomatic patients, genotyping of clinical isolates revealed that in pediatric cancer patients, CDI is not necessarily based on nosocomial transmission. The rate of CDI-related severe complications was low. What is Known: • Pediatric cancer patients face an increased risk of Clostridium difficile-associated disease due to immunosuppression, cancer chemotherapy, mucositis, and dysbiosis following intravenous broad-spectrum antimicrobial treatment. • C. difficile may be transmitted from patient to patient. What is New: • Under strict standard hygiene and contact isolation for symptomatic patients, genotyping of clinical isolates revealed that in pediatric cancer patients, CDI is not necessarily based on nosocomial transmission. • The rate of CDI-related severe complications was low.
Keyphrases
- clostridium difficile
- end stage renal disease
- newly diagnosed
- ejection fraction
- prognostic factors
- early onset
- squamous cell carcinoma
- palliative care
- genome wide
- high dose
- escherichia coli
- risk factors
- patient reported outcomes
- pseudomonas aeruginosa
- rectal cancer
- high throughput
- papillary thyroid
- drug induced
- genetic diversity