Subtyping CKD Patients by Consensus Clustering: The Chronic Renal Insufficiency Cohort (CRIC) Study.
Zihe ZhengSushrut S WaikarInsa M SchmidtJ Richard LandisChi-Yuan HsuTariq ShafiHarold I FeldmanAmanda H AndersonFrancis Perry WilsonJing ChenHernan Rincon-CholesAna C RicardoGeorges SaabTamara IsakovaRadhakrishna KallemJeffrey C FinkPanduranga S RaoDawei XieWei Yangnull nullPublished in: Journal of the American Society of Nephrology : JASN (2021)
Consensus clustering synthesized the patterns of baseline clinical and laboratory measures and revealed distinct CKD subgroups, which were associated with markedly different risks of important clinical outcomes. Further examination of patient subgroups and associated biomarkers may provide next steps toward precision medicine.