Antimicrobial and Cytotoxic Angucyclic Quinones from Actinomadura miaoliensis.
Siriporn SaepuaJittra KornsakulkarnWilunda ChoowongChanwit SuriyachadkunChollaratt BoonlarppradabChawanee ThongpanchangPublished in: Journal of natural products (2021)
Eight new angucyclic quinones, miaosporones A to H (1-8), along with the previously described metabolites 8-hydroxy-3-methylbenz[a]anthraquinone (9), tetrangulol (10), 5,6-dihydro-1,8-dihydroxy-3-methybenz[a]anthracene-7,12-quinone (11), and SF2315A (12), were isolated from the terrestrial actinomycete Actinomadura miaoliensis TBRC 5172 obtained from sediment collected from the Huai Yang reservoir, Prachuap Khiri Khan Province, Thailand. The relative and absolute configurations of the new compounds were determined from analysis of NMR spectroscopic and X-ray crystallographic data. Miaosporone A exhibited antimalarial activity against Plasmodium falciparum K1 and antibacterial activity against Mycobacterium tuberculosis with respective IC50 values of 2.5 and 2.4 μM and displayed cytotoxic activities against both cancerous (MCF-7 and NCI-H187) and nonmalignant (Vero) cells.
Keyphrases
- plasmodium falciparum
- mycobacterium tuberculosis
- high resolution
- induced apoptosis
- cell cycle arrest
- south africa
- molecular docking
- staphylococcus aureus
- magnetic resonance
- breast cancer cells
- electronic health record
- heavy metals
- ms ms
- magnetic resonance imaging
- big data
- computed tomography
- oxidative stress
- solid state
- artificial intelligence
- machine learning
- cell proliferation
- mass spectrometry
- contrast enhanced
- molecular dynamics simulations