Total Synthesis of Herquline B and C.
Joshua B CoxAoi KimishimaJohn L WoodPublished in: Journal of the American Chemical Society (2018)
The total syntheses of (-)-herquline B (2) and a heretofore-unrecognized congener, (+)-herquline C (3), are described. The syntheses require 14 and 13 steps, respectively, and feature a key oxazoline reduction that sets the stage for piperazine construction.