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Total Synthesis of Herquline B and C.

Joshua B CoxAoi KimishimaJohn L Wood
Published in: Journal of the American Chemical Society (2018)
The total syntheses of (-)-herquline B (2) and a heretofore-unrecognized congener, (+)-herquline C (3), are described. The syntheses require 14 and 13 steps, respectively, and feature a key oxazoline reduction that sets the stage for piperazine construction.
Keyphrases
  • machine learning
  • deep learning
  • neural network