Choroid Plexus Calcification Correlates with Cortical Microglial Activation in Humans: A Multimodal PET, CT, MRI Study.
T ButlerXiuyuan WangGloria C ChiangYi LiLiangdong ZhouK XiN WickramasuriyaE TanziE SpectorIlker OzsahinX MaoQolamreza R RazlighiE K FungJonathan P DykeT MaloneyAjay GuptaA RajDikoma C ShunguP David MozleyHenry RusinekLidia GlodzikPublished in: AJNR. American journal of neuroradiology (2023)
Choroid plexus calcification can be accurately and automatically quantified using low-dose CT and MRI. Choroid plexus calcification-but not choroid plexus volume-predicted cortical inflammation. Previously unmeasured choroid plexus calcium may explain recent reports of choroid plexus enlargement in human inflammatory and other diseases. Choroid plexus calcification may be a specific and relatively easily acquired biomarker for neuroinflammation and choroid plexus pathology in humans.
Keyphrases
- ultrasound guided
- pet ct
- low dose
- chronic kidney disease
- oxidative stress
- magnetic resonance imaging
- endothelial cells
- positron emission tomography
- traumatic brain injury
- inflammatory response
- computed tomography
- emergency department
- lps induced
- spinal cord
- brain injury
- induced pluripotent stem cells
- adverse drug
- electronic health record