Role of the anaphylatoxin receptor C5aR2 in angiotensin II induced hypertension and hypertensive end organ damage.
Leonie DreherMarlies BodeNicolas EhnertCatherine Meyer-SchwesingerThorsten WiechJörg KöhlTobias B HuberTilo FreiwaldGeorg R HerrnstadtUlrich O WenzelPublished in: American journal of hypertension (2024)
In summary, C5aR2 is mainly expressed on myeloid cells in the kidney in mice and humans but its deficiency has no effect in Ang II induced hypertensive injury.
Keyphrases
- angiotensin ii
- blood pressure
- high glucose
- diabetic rats
- angiotensin converting enzyme
- vascular smooth muscle cells
- induced apoptosis
- oxidative stress
- acute myeloid leukemia
- cell cycle arrest
- bone marrow
- endothelial cells
- dendritic cells
- type diabetes
- signaling pathway
- immune response
- skeletal muscle
- replacement therapy
- high fat diet induced