Adenosine diphosphate-induced aggregation is enhanced in platelets obtained from patients with thrombotic primary antiphospholipid syndrome (t-PAPS): Role of P2Y 12 -cAMP signaling pathway.
Guilherme Ruiz LeonardiCaroline Honaiser LescanoJose Luiz CostaBruna Mazetto FonsecaFernanda Andrade OrsiFabiola Zakia MonicaPublished in: Journal of thrombosis and haemostasis : JTH (2022)
receptor, accompanied by lower levels of cAMP and cGMP levels produced greater amplitude of ADP aggregation in platelets from t-PAPS patients.
Keyphrases
- signaling pathway
- end stage renal disease
- protein kinase
- binding protein
- ejection fraction
- chronic kidney disease
- newly diagnosed
- nitric oxide
- peritoneal dialysis
- prognostic factors
- epithelial mesenchymal transition
- high glucose
- pi k akt
- diabetic rats
- patient reported outcomes
- cell proliferation
- drug induced
- endoplasmic reticulum stress