Loss of MLL3/4 decouples enhancer H3K4 monomethylation, H3K27 acetylation, and gene activation during embryonic stem cell differentiation.

Ryan M BoileauKevin X ChenRobert Blelloch

Published in: Genome biology (2023)

Collectively, our study highlights gaps in knowledge about the steps and epistatic relationships of enzymes necessary for enhancer activation and cognate gene transcription.

Keyphrases

transcription factor
copy number
genome wide
genome wide identification
binding protein
healthcare
acute myeloid leukemia
gene expression
dna methylation
genome wide analysis
oxidative stress