Ligament injury in adult zebrafish triggers ECM remodeling and cell dedifferentiation for scar-free regeneration.

Troy Anderson Julia MoErnesto GagarinDesmarie SherwoodMaria H BlumenkrantzEric MaoGianna LeonHung-Jhen Chen Kuo-Chang Tseng Peter Fabian J Gage Crump Joanna Smeeton

Published in: bioRxiv : the preprint server for biology (2023)

Rapid regeneration of the jaw joint ligament in adult zebrafishDedifferentiation of mature ligamentocytes contributes to regenerationscRNAseq reveals dynamic ECM remodeling and immune activation during regenerationRequirement of Legumain for ECM remodeling and ligament healing.

Keyphrases

stem cells
extracellular matrix
anterior cruciate ligament
wound healing
single cell
cell therapy
childhood cancer
young adults
mesenchymal stem cells
bone marrow
sensitive detection