Biomarkers of Alzheimer's disease and cerebrovascular disease in relation to depressive symptomatology in individuals with subjective cognitive decline.
Mariola Zapater-FajaríPatricia Diaz-GalvanNira CedresTherese Rydberg SternerLina RydénSimona SacuiuMargda WaernAnna ZettergrenHenrik ZetterbergKaj BlennowSilke KernVanesa HidalgoAlicia SalvadorErik WestmanIngmar SkoogDaniel FerreiraPublished in: The journals of gerontology. Series A, Biological sciences and medical sciences (2023)
The role of depressive symptomatology in SCD may differ depending on the stage within the spectrum of preclinical AD (as determined by amyloid-beta and tau positivity), and does not seem to reflect AD pathology. Our findings contribute to the emerging field of subclinical depressive symptomatology in SCD, and clarify the association of different types of subjective complaints with distinct syndromic and biomarker profiles.