Acute lymphoblastic leukemia.
John Han-Chih ChangMatthew M PoppeChia-Ho HuaKaren J MarcusNatia EsiashviliPublished in: Pediatric blood & cancer (2021)
The survival of patients with acute lymphoblastic leukemia (ALL) has improved significantly with the use of intensive multimodality treatment regimens including chemotherapy, high-dose chemotherapy and stem cell rescue, and radiation therapy when indicated. This report summarizes the treatment strategies, especially radiation therapy in the Children's Oncology Group for children with ALL. Currently, radiation therapy is only indicated for children with high-risk CNS involvement at diagnosis or relapse, testicular relapse and as part of the conditioning regimen for hematopoietic stem cell transplantation. Future research strategies regarding the indications for and dosages of radiation therapy and novel radiation techniques are discussed.
Keyphrases
- radiation therapy
- acute lymphoblastic leukemia
- locally advanced
- young adults
- high dose
- radiation induced
- stem cells
- free survival
- allogeneic hematopoietic stem cell transplantation
- palliative care
- low dose
- rectal cancer
- acute myeloid leukemia
- blood brain barrier
- stem cell transplantation
- current status
- bone marrow
- combination therapy
- cell therapy
- chemotherapy induced