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Targeting glycolysis with 2-deoxy-D-glucose sensitizes primary cell cultures of renal cell carcinoma to tyrosine kinase inhibitors.

Adrian Georg SimonLaura Kristin EsserJörg EllingerVittorio BranchiYuri TolkachStefan MüllerManuel RitterGlen KristiansenMichael Helmut MudersThomas MayrMarieta Ioana Toma
Published in: Journal of cancer research and clinical oncology (2020)
This study presents a valuable tool to cultivate even uncommon and rare renal cancer subtypes and allows testing of targeted therapies as a personalized approach as well as testing new therapies such as glycolysis inhibition in an in vitro model.
Keyphrases
  • renal cell carcinoma
  • single cell
  • cell therapy
  • stem cells
  • squamous cell
  • type diabetes
  • induced apoptosis
  • skeletal muscle
  • bone marrow
  • insulin resistance
  • weight loss