Targeting glycolysis with 2-deoxy-D-glucose sensitizes primary cell cultures of renal cell carcinoma to tyrosine kinase inhibitors.
Adrian Georg SimonLaura Kristin EsserJörg EllingerVittorio BranchiYuri TolkachStefan MüllerManuel RitterGlen KristiansenMichael Helmut MudersThomas MayrMarieta Ioana TomaPublished in: Journal of cancer research and clinical oncology (2020)
This study presents a valuable tool to cultivate even uncommon and rare renal cancer subtypes and allows testing of targeted therapies as a personalized approach as well as testing new therapies such as glycolysis inhibition in an in vitro model.