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Single Nucleotide Variants in the TLR1, TLR2 and TLR6 Genes: A Case-Control Study in a Colombian Population.

Luz Dary Castañeda-CastañedaCarmen R AcostaMónica A BustosDiana K GarcíaDiana P BohadaRaúl RodríguezMartha Inirida Guerrero
Published in: Tropical medicine and infectious disease (2023)
The identified variants in the genes encoding TLRs, specifically rs5743810 in TLR6 and CGG (rs5743618-rs5743708-rs5743810) haplotypes, may somehow explain leprosy susceptibility in the studied population in a leprosy endemic region in Colombia.
Keyphrases
  • toll like receptor
  • inflammatory response
  • immune response
  • genome wide
  • copy number
  • nuclear factor
  • gene expression
  • genome wide identification
  • dna methylation
  • transcription factor