Novel tripeptide RKH derived from Akkermansia muciniphila protects against lethal sepsis.

Shihao XieJiaxin LiFengyuan LyuQingming XiongPeng GuYuqi ChenMeiling ChenJingna BaoXianglong ZhangRongjuan WeiYoupeng DengHongzheng WangZhenhua ZengZhongqing ChenYongqiang DengZhuoshi LianJie ZhaoWei GongYe ChenWei-Feng LiuYi DuanYong JiangHong-Wei Zhou Peng Chen

Published in: Gut (2023)

We revealed that a novel tripeptide, RKH, derived from live AKK, may act as a novel endogenous antagonist for TLR4. RKH may serve as a novel potential therapeutic approach to combat lethal sepsis after successfully translating its efficacy into clinical practice.

Keyphrases

clinical practice
septic shock
acute kidney injury
intensive care unit
toll like receptor
inflammatory response
immune response
single cell
nuclear factor