A novel large animal model of smoke inhalation-induced acute respiratory distress syndrome.

Premila D LeiphrakpamHannah R WeberAndrea McCainRoser Romaguera MatasErnesto Martinez DuarteKeely L Buesing

Published in: Respiratory research (2021)

This study reports, for the first time, a novel large animal model of isolated smoke inhalation-induced ARDS without confounding variables such as cutaneous burn injury. Use of this unique model may be of benefit in studying the pathophysiology of inhalation injury or for development of novel therapeutics.

Keyphrases

acute respiratory distress syndrome
extracorporeal membrane oxygenation
mechanical ventilation
high glucose
diabetic rats
drug induced
small molecule
oxidative stress
emergency department
intensive care unit
electronic health record