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The role of HIF-1α in nicotine-induced root and bone resorption during orthodontic tooth movement.

Niklas UllrichAgnes SchröderMaria BauerGerrit SpanierJonathan JantschJames DeschnerPeter ProffChristian Kirschneck
Published in: European journal of orthodontics (2021)
Study results indicate that the nicotine-induced increase in osteoclastogenesis and periodontal bone resorption during OTM may not be mediated by hypoxic effects or HIF-1α stabilization in the context of nicotine-induced vasoconstriction, but rather by an alternative mechanism.
Keyphrases
  • high glucose
  • diabetic rats
  • smoking cessation
  • bone loss
  • endothelial cells
  • drug induced
  • oxidative stress
  • soft tissue
  • inflammatory response
  • stress induced