The role of HIF-1α in nicotine-induced root and bone resorption during orthodontic tooth movement.

Niklas UllrichAgnes SchröderMaria BauerGerrit SpanierJonathan JantschJames DeschnerPeter ProffChristian Kirschneck
Published in: European journal of orthodontics (2021)
Study results indicate that the nicotine-induced increase in osteoclastogenesis and periodontal bone resorption during OTM may not be mediated by hypoxic effects or HIF-1α stabilization in the context of nicotine-induced vasoconstriction, but rather by an alternative mechanism.