Twenty-five-year trajectories of insulin resistance and pancreatic β-cell response and diabetes risk in nonalcoholic fatty liver disease.
Lisa B VanWagnerHongyan NingNorrina B AllenJuned SiddiqueApril P CarsonMichael P BancksCora E LewisJohn Jeffrey CarrElizabeth SpeliotesNorah A TerraultMary E RinellaMiriam B VosDonald M Lloyd-JonesPublished in: Liver international : official journal of the International Association for the Study of the Liver (2018)
Trajectories of insulin resistance and β-cell response during young and middle adulthood are robustly associated with diabetes risk in non-alcoholic fatty liver disease. Thus, how persons with non-alcoholic fatty liver disease develop resistance to insulin provides important information about risk of diabetes in midlife above and beyond degree of insulin resistance at the time of non-alcoholic fatty liver disease assessment.