In silico assessment of the effects of quinidine, disopyramide and E-4031 on short QT syndrome variant 1 in the human ventricles.

Cunjin LuoKuanquan WangHenggui Zhang

Published in: PloS one (2017)

The simulated pharmacological actions of quinidine exhibited antiarrhythmic effects on SQT1. This study substantiates a causal link between quinidine and QT interval prolongation in SQT1 and suggests that quinidine may be a potential pharmacological agent for treating SQT1 patients.

Keyphrases

end stage renal disease
drug induced
endothelial cells
ejection fraction
newly diagnosed
prognostic factors
induced pluripotent stem cells
risk assessment
molecular dynamics simulations
catheter ablation