Incretin combination therapy for the treatment of non-alcoholic steatohepatitis.

Aimo KanntAndreas Nygaard MadsenClaire KammermeierRalf ElvertTim KlöckenerMartin BossartTorsten HaackAndreas EversKatrin LorenzWolfgang HennericiCorinne RocherZsolt BöcskeiJean-Claude GuillemotVincent MikolFrancois PattouBart StaelsMichael Wagner

Published in: Diabetes, obesity & metabolism (2020)

GCGR and GIPR agonism provide additional, body weight-independent improvements on top of GLP-1R agonism in a murine model of manifest NASH with fibrosis.

Keyphrases

body weight
liver fibrosis
liver injury
combination therapy
smoking cessation