Multi-Omics Strategies Uncover Host-Pathogen Interactions.
Mohd M KhanOrna ErnstNathan P ManesBenjamin L OylerIain D C FraserDavid R GoodlettAleksandra Nita-LazarPublished in: ACS infectious diseases (2019)
With the success of the Human Genome Project, large-scale systemic projects became a reality that enabled rapid development of the systems biology field. Systems biology approaches to host-pathogen interactions have been instrumental in the discovery of some specifics of Gram-negative bacterial recognition, host signal transduction, and immune tolerance. However, further research, particularly using multi-omics approaches, is essential to untangle the genetic, immunologic, (post)transcriptional, (post)translational, and metabolic mechanisms underlying progression from infection to clearance of microbes. The key to understanding host-pathogen interactions lies in acquiring, analyzing, and modeling multimodal data obtained through integrative multi-omics experiments. In this article, we will discuss how multi-omics analyses are adding to our understanding of the molecular basis of host-pathogen interactions and systemic maladaptive immune response of the host to microbes and microbial products.
Keyphrases
- gram negative
- immune response
- single cell
- candida albicans
- multidrug resistant
- endothelial cells
- gene expression
- quality improvement
- high throughput
- transcription factor
- electronic health record
- toll like receptor
- pain management
- oxidative stress
- chronic pain
- artificial intelligence
- deep learning
- induced pluripotent stem cells