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Pharmacologic inhibition of hypoxia-inducible factor (HIF)-hydroxylases ameliorates allergic contact dermatitis.

Mario C ManresaLeila SmithLaura Casals-DiazRaphael R FagundesEric BrownPraveen RadhakrishnanStephen J MurphyBianca CrifoMoritz J StrowitzkiDoug N HalliganEllen H van den BogaardHanna NiehuesMartin SchneiderCormac T TaylorMartin Steinhoff
Published in: Allergy (2018)
These data demonstrate that hydroxylase inhibition attenuates the recruitment of neutrophils to inflamed skin through reduction of chemokine production and increased neutrophilic apoptosis. Thus, pharmacologic inhibition of HIF hydroxylases may be an effective new therapeutic approach in allergic skin inflammation.
Keyphrases
  • oxidative stress
  • soft tissue
  • endothelial cells
  • wound healing
  • endoplasmic reticulum stress
  • electronic health record
  • mouse model
  • allergic rhinitis
  • signaling pathway
  • atopic dermatitis
  • deep learning