Associations Between Gestational Diabetes Mellitus Risk and Folate Status in Early Pregnancy and MTHFR C677T Polymorphisms in Chinese Women.
Peng Ju LiuYanping LiuLiang-Kun MaAi Min YaoXiao Yan ChenYi Xuan HouLi Ping WuLiang Yu XiaPublished in: Diabetes, metabolic syndrome and obesity : targets and therapy (2020)
Higher RBC folate, partly caused by MTHFR 677C→T, may be associated with increased GDM risk, even in early pregnancy. Assessing RBC folate status and appropriately supplementing folate during early pregnancy, particularly for patients with MTHFR 677C→T, may prevent GDM. Further studies with larger populations are warranted.