Hepatic ultrastructural features distinguish paediatric Wilson disease from NAFLD and autoimmune hepatitis.

Saleh A Alqahtani Rose Chami Dua Abuquteish Shannon Marie VandrielCharesse YapLiyana KukkadiAishwarya ParmarAmrita MundhEve A RobertsBinita M KamathIram Siddiqui

Published in: Liver international : official journal of the International Association for the Study of the Liver (2022)

Light microscopic findings display considerable overlap among children with WD, NAFLD and AIH. Ultrastructural findings of mitochondrial abnormalities are important to distinguish WD from NAFLD and AIH. EM examination should be considered essential in the diagnostic work-up of paediatric liver biopsies.

Keyphrases

intensive care unit
emergency department
young adults
oxidative stress
multiple sclerosis
electron microscopy
drug induced