Adherence ability and serum resistance of different hospital clusters of Acinetobacter baumannii.
A P UberG F VianaF G LodiM M Dos Anjos SzczerepaF E Carrara-MarroniF GimenesS A B NishiyamaMaria Cristina Bronharo TognimPublished in: Letters in applied microbiology (2021)
The role of mechanical ventilation and catheters in favouring Acinetobacter baumannii infections needs to be better understood. This study evaluated the adherence of 19 isolates of different hospital clusters of A. baumannii to abiotic surfaces and epithelial cells (HEp-2). Of the hydrophobic isolates, 80% adhered to polystyrene, indicating a close relationship between hydrophobicity and adherence. All isolates adhered to epithelial cells to different degrees, and 73·7% showed an aggregated pattern. Analysis of the serum resistance of catheter-tip isolates showed that all were resistant. These worrisome results showed that the high capacity of A. baumannii to adhere to surfaces and survive in human serum could hinder treatment and control of this pathogen.
Keyphrases
- acinetobacter baumannii
- multidrug resistant
- drug resistant
- mechanical ventilation
- pseudomonas aeruginosa
- genetic diversity
- healthcare
- biofilm formation
- acute respiratory distress syndrome
- cystic fibrosis
- adverse drug
- glycemic control
- type diabetes
- respiratory failure
- candida albicans
- ionic liquid
- staphylococcus aureus
- escherichia coli
- extracorporeal membrane oxygenation
- aqueous solution