Efficient macrocyclization facilitated by skeleton preorganization.
Rong-Yao XuXiu LiuGuang SunZhi-Yuan ZhangMing DongLiya ZhaoSi-Miao ZhangXi-Yang WangHong-Xu ZhangShang-Jie YangXiuguang WangBin LiJian LiChunju LiPublished in: RSC advances (2023)
Reported here is the efficient macrocyclization facilitated by skeleton preorganization. A pyridylcarbazole macrocycle and a phenylpyridylcarbazole macrocycle was synthesized in yield up to 75%. Single-crystal structures and theoretic computation uncovered that the skeleton preorganization promoted the formation of cyclization-favorable conformation of noncyclic precursors via π⋯π interactions. This result provided a new approach for the efficient syntheses of macrocycles.
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