The crystal structure of a natural DNA polymerase complexed with mirror DNA.
Jinsu AnJaewoo ChoiDohyeon HwangJihyun ParkCharles W PembleThi Hoai Men DuongKyoung-Ran KimHeechul AhnHak Suk ChungDae-Ro AhnPublished in: Chemical communications (Cambridge, England) (2020)
The intrinsic l-DNA binding properties of a natural DNA polymerase was discovered. The binding affinity of Dpo4 polymerase for l-DNA was comparable to that for d-DNA. The crystal structure of Dpo4/l-DNA complex revealed a dimer formed by the little finger domain that provides a binding site for l-DNA.