Metformin and rapamycin protect cells from vital dye-induced damage in retinal pigment epithelial cells and in vivo.

Chih-Wen ShuChui-Lien TsenMeng-Syuan LiYoun-Shen BeeShi-Han LinShwu-Jiuan Sheu

Published in: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie (2020)

Taken together, these results suggest that rapamycin and metformin may diminish vital dye-induced retinal damage in vivo through activation of autophagy.

Keyphrases

oxidative stress
diabetic rats
high glucose
cell death
signaling pathway
optical coherence tomography
highly efficient
endoplasmic reticulum stress
endothelial cells
optic nerve