A Concise Route to Keto-Bridged Polyphenols by Photo-Fries Rearrangement in Flow.
Xin-Jie LinChien-Lung WangChi-How PengHsueh-Ju LiuYen-Ku WuPublished in: Chemistry, an Asian journal (2024)
Described is a new synthetic route to bis(2-hydroxy-3,5-di-t-butylphenyl)methanone and its derivatives. The combined esterification/photo-Fries rearrangement approach enables a modular preparation of keto-bridged polyphenols. This protecting group-free process is highly atom- and step-economic, and a scalable production was easily achieved in the continuous-flow mode.