Evaluation of inherited germline mutations in cancer susceptibility genes among pancreatic cancer patients: a single-center study.
Francesca TavanoDomenica GioffredaAndrea FontanaOrazio PalmieriAnnamaria GentileTiziana LatianoAnna LatianoTiziana Pia LatianoMatteo ScaramuzziEvaristo MaielloFrancesca BazzocchiFrancesco PerriPublished in: Molecular medicine (Cambridge, Mass.) (2023)
This study confirmed the potential remarkable contribution of BRCA2 in assessing the presence of PanC. Overall our findings supported the recommendation of offering the germline testing to all the PanC patients with the intent to reduce the number of underdiagnosed carriers of mutations in predisposition genes, and not to preclude their relatives from the opportunity to benefit from surveillance programs.
Keyphrases
- end stage renal disease
- public health
- genome wide
- newly diagnosed
- ejection fraction
- chronic kidney disease
- dna repair
- prognostic factors
- papillary thyroid
- peritoneal dialysis
- bioinformatics analysis
- gene expression
- squamous cell carcinoma
- genome wide identification
- young adults
- dna methylation
- squamous cell
- patient reported outcomes
- genome wide analysis
- childhood cancer