Neonatal protection and preterm birth reduction following maternal group B streptococcus vaccination in a mouse model.
R BernardiniR AufieriA DetchevaS RecchiaR CicconiM AmicosanteC MontesanoP RossiH K TchidjouB PetrunovG OreficiMaurizio MatteiPublished in: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians (2016)
Our finding suggest that vaccinated mothers could protect their progeny from GBS infection and preterm birth through passive immunization. The proposed mouse model may represent a noninvasive and effective tool to investigate pathogenetic mechanisms of GBS ascending infection and for vaccine protection studies.