Protectin conjugates in tissue regeneration 1 alleviates sepsis-induced acute lung injury by inhibiting ferroptosis.

Ya LvDeming ChenXinyi TianJi XiaoCongcong XuLinan DuJiacong LiSiyu ZhouYuxiang ChenRong ZhuangYuqiang GongBinyu YingFang Gao-SmithShengwei JinYe Gao

Published in: Journal of translational medicine (2023)

This study suggests that PCTR1 suppresses LPS-induced ferroptosis via the ALX/PKA/CREB signaling pathway, which may offer promising therapeutic prospects in sepsis-related ALI.

Keyphrases

signaling pathway
lps induced
cell death
inflammatory response
intensive care unit
septic shock
acute kidney injury
pi k akt
stem cells
induced apoptosis
epithelial mesenchymal transition
mouse model