Therapeutic and Preventive Effects of Osteoclastogenesis Inhibitory Factor on Osteolysis, Proliferation of Mammary Tumor Cell and Induction of Cancer Stem Cells in the Bone Microenvironment.
Mitsuru FutakuchiTakao NitandaSaeko AndoHarutoshi MatsumotoEri YoshimotoKatsumi FukamachiMasumi SuzuiPublished in: International journal of molecular sciences (2018)
While receptor activator of NF-κB ligand (RANKL) targeting therapy may not affect the induction of CSCs, RANKL is a potential target for prevention as well as treatment of breast cancer bone metastasis.
Keyphrases
- bone loss
- cancer stem cells
- nuclear factor
- signaling pathway
- bone mineral density
- toll like receptor
- lps induced
- cell therapy
- stem cells
- single cell
- bone regeneration
- soft tissue
- oxidative stress
- cancer therapy
- pi k akt
- postmenopausal women
- drug delivery
- young adults
- mesenchymal stem cells
- combination therapy
- climate change
- immune response