Pathological neurons generate ripples at the UP-DOWN transition disrupting information transfer.
Shennan Aibel WeissItzhak FriedJerome EngelAnatol BraginShuang WangMickael R SperlingRobert K S WongYuval NirRichard J StabaPublished in: Epilepsia (2023)
The UP-DOWN transition of slow wave excitability facilitates the activation of pathological neurons to generate pHFOs. Ripple temporal correlations across brain regions may be important in memory consolidation and are disrupted in the SOZ, perhaps by pHFO generation.