Dihydroisotanshinone I regulates ferroptosis via PI3K/AKT pathway to enhance cisplatin sensitivity in lung adenocarcinoma.

Feng-Jiao Li Li-Chen Gao Hui-Zhi Long Zi-Wei Zhou Hong-Yu Luo Shuo-Guo Xu Shang-Ming Dai Jin-Da Hu

Published in: The Journal of pharmacy and pharmacology (2024)

Consequently, we concluded that DT promotes ferroptosis in cisplatin-resistant LAUD A549/DDP cells. Additionally, DT reverses cisplatin resistance by promoting ferroptosis via PI3K/MDM2/P53 pathway in A549/DDP cells.

Keyphrases

cell death
induced apoptosis
cell cycle arrest
endoplasmic reticulum stress
signaling pathway
oxidative stress