Effects of Developmental Lead and Phthalate Exposures on DNA Methylation in Adult Mouse Blood, Brain, and Liver Identifies Tissue- and Sex-Specific Changes with Implications for Genomic Imprinting.
Rachel K MorganKai WangLaurie K SvobodaChristine A RygielClaudia LalancetteRaymond CavalcanteMarisa S BartolomeiRexxi PrasasyaKari NeierBambarendage P U PereraTamara R JonesJustin A ColacinoMaureen A SartorDana C DolinoyPublished in: bioRxiv : the preprint server for biology (2023)
We observed Pb- and DEHP-specific DNAm changes in cortex, blood, and liver, and the greatest degree of overlap in DMR signatures was seen between exposures followed by sex and tissue type. DNAm at imprinted control regions was altered by both Pb and DEHP, highlighting the susceptibility of genomic imprinting to these exposures during the perinatal window of development.