Fabrication of a Terbium-Functionalized Cadmium Organic Framework with Proper Energy Levels as a Ratiometric Probe of an Anthrax Biomarker.
Hui-Hui XieLi-Wen WangSi-Fu TangPublished in: Inorganic chemistry (2024)
Anthrax bacillus is a very dangerous zoonotic pathogen that seriously endangers public health. Rapid and accurate qualitative and quantitative detection of its biomarkers, 2,6-dipicolinic acid (DPA), is crucial for the prevention and treatment of this pathogenic bacterium. In this work, a novel Cd-based MOF (TTCA-Cd) has been synthesized from a polycarboxylate ligand, [1,1':2',1″-terphenyl]-4,4',4″,5'-tetracarboxylic acid (H 4 TTCA), and further doped with Tb(III), forming a dual-emission lanthanide-functionalized MOF hybrid (TTCA-Cd@Tb). TTCA-Cd@Tb can be developed as a high-performance ratiometric fluorescent sensor toward DPA with a very low detection limit of 7.14 nM and high selectivity in a wide detection range of 0-200 μM, demonstrating a big advancement and providing a new option for the detection of DPA.
Keyphrases
- quantum dots
- loop mediated isothermal amplification
- public health
- label free
- sensitive detection
- living cells
- mycobacterium tuberculosis
- real time pcr
- metal organic framework
- high resolution
- fluorescent probe
- nk cells
- photodynamic therapy
- energy transfer
- mass spectrometry
- risk assessment
- highly efficient
- heavy metals
- machine learning
- candida albicans
- molecularly imprinted
- tandem mass spectrometry
- bacillus subtilis