Inflammasome formation in the lungs of patients with fatal COVID-19.

Stefano ToldoRossana BussaniVincenzo NuzziAldo BonaventuraAdolfo G MauroAntonio CannatàRaghavendra PillappaGianfranco SinagraPatrick Nana-SinkamPatricia SimeAntonio Abbate

Published in: Inflammation research : official journal of the European Histamine Research Society ... [et al.] (2020)

These findings identify the presence of NLRP3 inflammasome aggregates in the lungs of fatal COVID-19 pneumonia thus providing the potential molecular link between viral infection and cytokine release syndrome.

Keyphrases

nlrp inflammasome
coronavirus disease
sars cov
respiratory syndrome coronavirus
case report
intensive care unit
respiratory failure
community acquired pneumonia