Transfusion-associated circulatory overload-a systematic review of diagnostic biomarkers.

Robert B Klanderman Joachim J BosboomYazan MigdadyDenise P VeeloBart F GeertsMichael F MurphyAlexander P J Vlaar

Published in: Transfusion (2018)

Currently, BNP and NT-proBNP are the primary diagnostic biomarkers researched for TACO. An NT-proBNP ratio greater than 1.5 is supportive of TACO, and low levels of BNP or NT-proBNP can exclude TACO. However, they are unreliable in critically ill patients. Other biomarkers, including cytokines and pulmonary edema fluid-to-serum protein ratio have not yet been sufficiently investigated for clinical use.

Keyphrases

cardiac surgery
extracorporeal membrane oxygenation
mass spectrometry
high resolution
small molecule
binding protein