Targeting BRD4 attenuates the stemness and aggressiveness of ameloblastoma.

Jiaxiang XieJingqi ZhangGan XiongShengqi OuyangBokai YunXiuyun XuWenjin WangMing ZhangNan XieDemeng ChenCheng Wang

Published in: Oral diseases (2023)

BRD4 increases the aggressiveness and promotes the recurrence of ameloblastoma by regulating the Wnt pathway and stemness-associated pathways. These findings highlight BRD4 as a promising therapeutic target in AM management.

Keyphrases

stem cells
epithelial mesenchymal transition
cell proliferation
cancer therapy
cancer stem cells
drug delivery