Pharmacological, toxicological and phytochemical analysis of Spondias dulcis parkinson.
Felipe Hugo Alencar FernandesSabrina da Silva SoaresElmira BekbolatovaFábio BoylanHérida Regina Nunes SalgadoPublished in: Natural product research (2023)
Spondias dulcis Parkinson have been used in traditional medicine in Asia, Oceania, and South America, for different diseases conditions and as a functional food. The scientific literature described as different potential pharmacology such as antioxidant, anti-inflammatory, antimicrobial, thrombolytic and enzymatic inhibitor. This study aimed to: (1) establish the pharmacological activity in intestinal motility in vivo and antioxidant activity in vitro ; (2) perform the acute toxicology test in mouse; (3) characterize the phytochemical profile based on counter-current chromatography (CCC) and NMR analysis. The results revealed a laxative effect of S. dulcis extract and a high antioxidant activity (IC50 = 5.10 for DPPH assay and 14.14 for hydrogen peroxide scavenging test). No side effects were observed in the oral acute toxicity test for a dose up to 2000 mg/kg. The chemical profile was identified by CCC and NMR, and the comparison of the data obtained with previous literature revealed the presence of the flavonoid rutin (Quercetin-3-O-rutinoside) in the extract.
Keyphrases
- hydrogen peroxide
- anti inflammatory
- oxidative stress
- liver failure
- magnetic resonance
- systematic review
- respiratory failure
- nitric oxide
- high resolution
- aortic dissection
- single cell
- drug induced
- mass spectrometry
- solid state
- pulmonary embolism
- electronic health record
- high throughput
- human health
- liquid chromatography
- escherichia coli
- artificial intelligence
- intensive care unit
- tandem mass spectrometry
- ms ms
- risk assessment
- extracorporeal membrane oxygenation
- mechanical ventilation
- machine learning
- acute respiratory distress syndrome