Investigating in VigiBase over 6000 cases of pneumonia in clozapine-treated patients in the context of the literature: focus on high lethality and the association with aspiration pneumonia.
Jose De LeonCan-Jun RuanGeorgios SchoretsanitisAlejandro G Villasante-TezanosEdoardo SpinaEmílio J SanzMoisés BetancortCarlos de Las CuevasPublished in: Expert opinion on drug metabolism & toxicology (2024)
In clozapine-treated patients: 1) at least 30% of pneumonia cases may be aspiration pneumonia, 2) stopping some co-medications may decrease the risk of aspiration pneumonia, 3) average lethality in pneumonia was 45% but may be around 75% in geriatric patients with long-term treatment, and 4) safer titrations may sometimes require 5-mg tablets.
Keyphrases
- respiratory failure
- community acquired pneumonia
- ultrasound guided
- end stage renal disease
- chronic kidney disease
- systematic review
- ejection fraction
- intensive care unit
- patient reported outcomes
- extracorporeal membrane oxygenation
- combination therapy
- replacement therapy
- acute respiratory distress syndrome
- mechanical ventilation