LINC00460/DHX9/IGF2BP2 complex promotes colorectal cancer proliferation and metastasis by mediating HMGA1 mRNA stability depending on m6A modification.

Pingfu HouSen MengMinle LiTian LinSufang ChuZhongwei LiJun-Nian ZhengYuming GuJin Bai

Published in: Journal of experimental & clinical cancer research : CR (2021)

LINC00460 may be a novel oncogene of CRC through interacting with IGF2BP2 and DHX9 and bind to the m6A modified HMGA1 mRNA to enhance the HMGA1 mRNA stability. LINC00460 can serve as a promising predictive biomarker for the diagnosis and prognosis among patients with CRC.

Keyphrases

long non coding rna
binding protein
long noncoding rna
cell proliferation
pi k akt
signaling pathway
growth hormone