Neuroepigenetic alterations in the prefrontal cortex of type 2 diabetic mice through DNA hypermethylation.
Valencia FernandesAnika SoodKumari PreetiDharmendra Kumar KhatriShashi Bala SinghPublished in: Molecular biology reports (2022)
Overall, our study concludes the plausible involvement of neuroepigenetic alterations in the prefrontal cortex (PFC) of the type 2 diabetes mice, specifically DNA hypermethylation. PFC plays a central role in modulating cognitive and other executive functions through its connection with several brain regions, and thus therapeutic strategies targeting epigenetic modulations in it, can pave a way in controlling several neurological alterations in the brain.
Keyphrases
- prefrontal cortex
- type diabetes
- circulating tumor
- resting state
- white matter
- cell free
- single molecule
- cerebral ischemia
- gene expression
- dna methylation
- functional connectivity
- cardiovascular disease
- insulin resistance
- signaling pathway
- cancer therapy
- high fat diet induced
- adipose tissue
- multiple sclerosis
- subarachnoid hemorrhage
- glycemic control
- metabolic syndrome