The Clinical Relevance of the Infiltrating Immune Cell Composition in Kidney Transplant Rejection.

Thibaut Vaulet Jasper Callemeyn Baptiste Lamarthée Asier Antoranz Tim Debyser Priyanka Koshy Dany Anglicheau Jill Colpaert Wilfried Gwinner Philip F Halloran Dirk R J KuypersClaire TinelAmaryllis H Van Craenenbroeck Elisabet Van Loon Pierre Marquet Francesca Maria Bosisio Maarten Naesens

Published in: Journal of the American Society of Nephrology : JASN (2024)

Although some specific cell types (FCGR3A+ myeloid cells, CD14+ monocytes/macrophages and NK cells), partly discriminate between rejection phenotypes, the overall estimated immune cell composition of kidney transplants is ill related to main Banff-defined rejection categories and adds to the Banff lesion scoring and evaluation of rejection severity. The estimated intragraft CD8temra cells bear strong and consistent association with graft failure and independent of Banff-grade rejection.

Keyphrases

nk cells
induced apoptosis
cell cycle arrest
dendritic cells
endoplasmic reticulum stress
single cell
acute myeloid leukemia
immune response
cell proliferation