Interaction between Continuous Pack-Years Smoked and Polygenic Risk Score on Lung Cancer Risk: Prospective Results from the Framingham Heart Study.

Meredith S Duncan Hector Diaz-Zabala James Jaworski Hilary A Tindle Robert A Greevy Loren Lipworth Rayjean J Hung Matthew S Freiberg Melinda C Aldrich

Published in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology (2024)

These results underscore the contributions of genetics and smoking on lung cancer risk and highlight the negative impact of continued smoking regardless of genetic risk.

Keyphrases

smoking cessation
dna methylation
copy number
gene expression