Detection of drug resistant Mycobacterium tuberculosis by high-throughput sequencing of DNA isolated from acid fast bacilli smears.
Mazhgan RownekiNaomi AronsonPeicheng DuPaige SachsRobert BlakemoreSoumitesh ChakravortyShawn LevyAngela L JonesGeetika TrivediSheilla CheboreDennis AddoDenis K ByarugabaPanganani Dalisani NjobvuFrederick Wabwire-MangenBernard ErimaEric S RamosCarlton A EvansBraden HaleJames D MancusoDavid AllandPublished in: PloS one (2020)
This rapid AFB smear DNA-based method for determining drug resistance may be useful for the diagnosis and surveillance of drug-resistant tuberculosis.
Keyphrases
- drug resistant
- mycobacterium tuberculosis
- pulmonary tuberculosis
- multidrug resistant
- high throughput sequencing
- circulating tumor
- gram negative
- acinetobacter baumannii
- loop mediated isothermal amplification
- cell free
- single molecule
- public health
- emergency department
- label free
- circulating tumor cells
- hiv aids
- hiv infected
- quantum dots
- antiretroviral therapy