Onset of progressive motor impairment in patients with critical central nervous system demyelinating lesions.
Roman M KassaElia SechiEoin Patrick FlanaganTimothy J KaufmannOrhun H KantarciBrian G WeinshenkerJay MandrekarWilliam F SchmalstiegM Mateo Paz SoldanB Mark KeeganPublished in: Multiple sclerosis (Houndmills, Basingstoke, England) (2020)
Motor-progression age is similar, but paradoxically earlier, in cohorts with highly restricted CNS lesion burden than in those with unrestricted lesion burden with progressive unilateral hemiparetic MS. The "critical" demyelinating lesion rather than total brain MRI lesion burden is the major contributor to motor-progression onset in these cohorts.