TOP-Plus is a Versatile Biosensor Platform for Monitoring SARS-CoV-2 Antibody Durability.

Sabrina E Racine-BrzostekMohsen KarbaschiChristian GaeblerP J KlasseJim YeeMarina CaskeyHe S YangYing HaoAmy ChadburnYuanyuan ShiRobert ZukMichel C NussenzweigMelissa M CushingZhen Zhao

Published in: medRxiv : the preprint server for health sciences (2021)

The newly designed avidity assay in this TOP panel correlated well with a reference Bio-Layer Interferometry avidity assay (R=0.88). The imprecision of the TOP avidity assay was less than 9%. Although TAb and neutralization activity (by SNAb) decreased between 1.3 and 6.2 months post infection, the antibody avidity increased significantly (P < 0.0001).

Keyphrases

high throughput
sars cov
gold nanoparticles
quantum dots
respiratory syndrome coronavirus
single cell
mass spectrometry